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CBD???s and Cancer, Some Facts You May Not Know.

Posted by alexandriaelkwood on July 5, 2017 at 11:20 AM Comments comments (0)




SPIKE BOWAN JUNE 29, 2017

It doesn’t get much more controversial than the topic of CBD, Medical Cannabis and the treatments that they can offer when it comes to medical afflictions.


Ironically, the argument against the use of medicinal marijuana and cannabinoids stem from pharmaceutical companies and/or doctors/hospitals that may or may not be backed by big pharma. Especially when it comes to cancer treatment.


Marijuana has been used in herbal remedies for centuries. Scientists have identified many biologically active components in marijuana called cannabinoids. The two best studied components are the chemicals delta-9-tetrahydrocannabinol (often referred to as THC), and cannabidiol (CBD).


Advocates, that are championing the use of CBD and THC therapy for the treatment of cancer patients have a long and lengthy battle ahead of them. However, the evidence of how CBD can eradicate cancer cells, grows exponentially each day.


Pain management, reducing nausea from chemotherapy the benefits of CBD/THC therapy are staggering. Studies have long shown that people who took marijuana extracts in clinical trials tended to need less pain medicine. How about killing cancer all together?


More recently, scientists reported that THC and other cannabinoids such as CBD, slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.


When it comes to medicine, I rely on proof and cold hard science. The fact is, the proof is in the pudding. Bio-Chemist Dennis Hill breaks it down quite elegantly. How cancer cells are targeted and eliminated by CBD and THC.


He says,


“Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.


The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.


Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.”


Basically, Mr. Hill is saying that the cancer cells are eliminated by the CBD and THC, preventing any chance of cancer cell survival… So why wouldn’t we be interested in this? There are varying opinions on this. I will give you the facts as I find them and let you make your own decisions.


The US Drug Enforcement Administration (DEA) lists marijuana and its cannabinoids as Schedule I controlled substances. This means that they cannot legally be prescribed, possessed, or sold under federal law. Uncle Sam says “NO!” so we are to obey and accept this fact, right?


CBD and THC can kill cancer, why aren’t we curing the world then? Why the heavy regulation by the government? Why aren’t pharmaceutical companies jumping on this?


You know why. And now, all of the sudden, there is Dronabinol. A pharmaceutical form of THC, and also a man-made cannabinoid drug called nabilone are approved by the FDA to treat some conditions.


The facts are out there, CBD and THC work to fix many ailments and diseases, but big pharma just needs to step out of the way or jump on the pro-CBD band wagon and stop worrying about there wallets.

Can Cannabis Be Used to Treat Insomnia?

Posted by alexandriaelkwood on July 5, 2017 at 11:10 AM Comments comments (0)

Can Cannabis Be Used to Treat Insomnia?

MEREDITH SUMMERS JUNE 30, 2017

Sleep is truly a beautiful thing to us all — except of course when you can’t seem to get any of it. Insomnia causes problems across the world, from the exhausted driver to the perpetually wired doctor. It can make people moody, or even downright mean. The effects are so universal that even if you’ve never had a problem with sleep, you have a reason besides altruism to ensure that others aren’t missing their Zs.


More than one in three adults understand exactly what it feels like to get less than a full night’s sleep, and practically all of those adults know how difficult it is to find solutions to their (very real) problem. But what if cannabis was the key to unlocking the solution?

CBD stands for cannabidiol, and is specifically meant to relax the user without causing the giddy feelings generally associated with cannabis. Find out more about how how sleep works, and how the more traditional medicine stacks up to CBD.


The Science of Sleep

When the sun goes down and you start yawning, your brain is actually sending signals back and forth to your spine. The pineal gland in your brain will then create natural melatonin, so you can actually rest. (Melatonin is derived from tryptophan which is stored in the pineal gland.) The theory behind cannabis and sleep is that cannabis will actually mimic the chemicals your brain is supposed to produce. It means you fall asleep faster, stay asleep longer, and even breath better while you’re asleep.



Evidence of Help

Despite legality in some form or another in 29 states, marijuana is still illegal at the federal level. Unfortunately, that makes research somewhat scarce about its effects. There was one study done years ago which found marijuana helped people fall asleep. Another study showed that using CBD several hours before bed helps people balance out their energy, so they can sleep through the night without anxiety. And of course, anecdotal evidence is strong that this is more than just a casual relationship between the two activities.


Tips for Better Sleep

Not every type of cannabis will help people feel sleepy immediately. Cannabinol (CBN) is is the sedation chemical that’s produced when THC starts to age, and it’s rather effective when it comes to using it right before you want to sleep. However, for a more relaxing evening that lasts for several hours, CBD oil promotes better sleep by relaxing the mind enough to stimulate natural melatonin. Pairing this with natural remedies (e.g., chamomile tea) can actually make the cannabis even more effective. 


Days of Comparisons

There are plenty of over-the-counter treatments for insomnia, as well as more serious prescription remedies. While we all have different body chemistries, these choices are often physically addictive and can cause extreme reactions in some people. Ambien has been linked to suicidal thoughts and extremely odd behavior. Natural sleeping pills or drinks may do little to treat the more extreme cases, leaving people in despair when they are still unable to sleep. Nevertheless, sleep aids are set to be a $10 billion industry by 2020. Considering even small doses of cannabis can help an insomniac, it makes this choice a much smarter, cost-conscious alternative.


Safety and You

CBD is non-habit forming, which definitely can’t be said for the prescription drugs. While it can become psychologically addictive, it’s generally considered both safe and effective in comparison to the other choices on the market. However, it should be noted that cannabis is not meant to be the sole answer to insomnia.


Other Solutions

Generally speaking, it’s some type of stress or anxiety that insomniacs need to work through, so the body can keep up its natural defenses. Just like a cup of chamomile tea can help relax the body enough for the melatonin to take over, so too can more involved solutions such as meditation or psychotherapy. However, CBD oil can be used in addition to these measures as a long-term means to get the sleep the body needs to stay healthy — both physically and mentally.

Natural Alternative for Bone Disorders

Posted by alexandriaelkwood on May 13, 2017 at 6:35 PM Comments comments (0)

Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health.

 

Putnam SE1, Scutt AM, Bicknell K, Priestley CM, Williamson EM.

Author information

Abstract

Bone metabolism involves a complex balance between the deposition of matrix and mineralization and resorption. There is now good evidence that dietary components and herbal products can influence these processes, particularly by inhibiting bone resorption, thus having beneficial effects on the skeleton. For example, it has been reported that a number of common vegetables, including onion, garlic and parsley, can inhibit bone resorption in ovariectomized rats. Essential oils derived from sage, rosemary, thyme and other herbs inhibit osteoclast activity in vitro and in vitro and leading to an increase in bone mineral density. Soya, a rich source of isoflavones, has shown promising results and epidemiological evidence to support a use in maintaining bone health, and various traditional herbal formulae in Chinese and Ayurvedic medicine also have demonstrable effects in pharmacological models of osteoporosis. Recently, cannabinoids have been described as having positive effects on osteoblast differentiation, and the presence of cannabinoid receptors in bone tissue indicates a more complex role in bone metabolism than previously thought. The first part of this review briefly discusses normal bone metabolism and disorders caused by its disruption, with particular reference to osteoporosis and current pharmacological treatments. The effects of natural products on bone and connective tissue are then discussed, to include items of diet, herbal extracts and food supplements, with evidence for their efficacy outlined.

Copyright (c) 2006 John Wiley & Sons, Ltd.

 

PMID: 17106868 DOI: 10.1002/ptr.2030

[Indexed for MEDLINE]

Osteoporosis - CB & TRPV1 Receptors

Posted by alexandriaelkwood on May 13, 2017 at 6:25 PM Comments comments (0)

The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy.

 

Rossi F1, Bellini G, Luongo L, Torella M, Mancusi S, De Petrocellis L, Petrosino S, Siniscalco D, Orlando P, Scafuro M, Colacurci N, Perrotta S, Nobili B, Di Marzo V, Maione S; Endocannabinoid Research Group (ERG), Italy.

Author information

Abstract

Human osteoclasts express functional TRPV1 channels, CB1/CB2 cannabinoid receptors and endocannabinoid/endovanilloid synthetic/catabolic enzymes. Pharmacologic manipulation of this system can modulate osteoclast activity. Here, through multidisciplinary approaches, we demonstrate that enzymes and receptors of the endocannabinoid/endovanilloid system are differently expressed in osteoclasts from menopausal women without or with osteoporosis. We report that in osteoclasts from osteoporotic patients, TRPV1 channels are upregulated and, if persistently stimulated with resiniferatoxin, become clustered to the plasma membrane while inducing a massive over-expression of CB2 receptors. By providing new evidence for a critical functional cross-talk between CB2 and TRPV1 receptors in osteoporosis, we speculate that TRPV1 desensitization, or its enhanced trafficking, together with TRPV1 agonist-induced CB2 receptor overexpression, might be critical to minimize calcium entry in osteoclasts, which could be in turn responsible of cell over-activation and higher bone resorption. Our data pave the way to the use of TRPV1 agonist together with CB2 agonists or CB1 antagonists in osteoporosis.

Copyright © 2011. Published by Elsevier Inc.

 

PMID: 21237298 DOI: 10.1016/j.bone.2011.01.001

[Indexed for MEDLINE]

Cannabinoids Show Promise In Protecting Brain From Inflammation

Posted by alexandriaelkwood on April 13, 2017 at 5:10 PM Comments comments (0)

Cannabinoids Show Promise In Protecting Brain From Inflammation

 

ALZHEIMER'S HEALTH — SEP 25, 2013

 

The blood-brain barrier. (Photo: Wikimedia Commons/Ben Brahim Mohammed)

Researchers from Temple University School of Medicine have found more evidence supporting the use of marijuana-based treatments in Alzheimer’s disease, stroke and multiple sclerosis.

 

Inflammation is a common factor in the progression of each of these disorders. But previous studies suggest that marijuana can help control inflammation by acting on specific pathways present in immune cells.

 

In the latest study, Dr. Yuri Persidsky of Temple University and his team studied the role of these pathways, CB2 receptors, using human cell cultures. Published this month in the American Journal of Pathology, they concluded that activating CB2 receptors could reduce brain tissue damage by preventing immune cells from crossing from the blood stream into the brain.

 

These results indicate that selective CB2 activation in leukocytes decreases key steps in monocyte-BBB [blood-brain barrier] engagement, thus suppressing inflammatory leukocyte responses and preventing neuroinflammation.

 

Shilpa Buch, Ph.D, a professor at the Nebraska Medical Center’s Department of Pharmacology and Experimental Neuroscience, noted the importance of the new findings in an accompanying commentary.

 

None of the previous studies have addressed anti-inflammatory effects of CB2 activation in monocytes in such a comprehensive fashion.

 

According to Dr. Buch, the migration of immune cells called monocytes plays a critical role in a wide variety of inflammatory diseases.

 

The development and maintenance of chronic inflammation appear to be underlying causes of numerous human diseases such as atherosclerosis, obesity, diabetes, arthritis, chronic hepatitis, bone disorders, and neurodegeneration (including Alzheimer’s disease, multiple sclerosis and chronic infections of the central nervous system like HIV-1). In all of these diseases, tissue infiltration by monocytes differentiating into macrophages plays a critical role.

 

Some studies suggest that stimulating CB1 pathways – which are found mostly in the brain and are responsible for the marijuana high – may also have anti-inflammatory potential.

 

But as Dr. Buch notes, treatments “devoid of the psychoactive effects of CB1 activation” are preferred by doctors.

 

And while a CB2-specific treatment has yet to be tested in humans, she adds that previous studies have already shown promising results in animal models of atherosclerosis, multiple sclerosis, Alzheimer’s disease, liver and kidney injury and arthritis.

 

The study was published ahead of print and received funding from the National Institutes of Health and the Intramural Research Program of the NIH-NIAAA

8 Cannabinoids That are a Must

Posted by alexandriaelkwood on April 12, 2017 at 2:50 PM Comments comments (0)

The 8 Cannabinoids That Interact With You The Most

Cannabinoids are the compounds found in the cannabis plant. Scientists think that as of now, there are more than 480 existing cannabinoids found in the plant but we only know less than 70 of them – we’re barely scratching the surface.

THC

Tetrahydrocannabinol (THC) is the most widely known cannabinoid in marijuana. THC is responsible for the plant’s psychoactive effects; in short, it’s what gets you high. While THC has known medicinal properties, it’s also what gets the most controversy about marijuana use.

THC is used for pain relief, stress, PTSD, nausea, vomiting, appetite stimulant, asthma, glaucoma, insomnia.


THCv

Tetrahydrocannabivarin (THCV) is found in cannabis plants originating from central Africa, like phenotypes from Malawi. THCV affects the same receptors in the brain that THC does although it’s known to produce a different kind of high. THCV is psychedelic but it gives more of a clear-headed feel. Some of the most famous sativas in the world are actually high in THCV especially those that come from African landraces such as Durban Poison and the famous Haze strains. 

THCV is still being studied for specific uses: one, its use as a potential appetite suppressant (THCV is an antagonist of CB1 and CB2 receptors; scientists believe that it blocks the feeling of reward that we feel when we eat food). THCV is also effective as an anticonvulsant.


THCa 

Tetrahydrocannabinolic Acid (THCa) is the main compound found in raw cannabis. It converts to D9-THC when it is exposed to heat, burned, or vaporized at a certain temperature. THCa won’t produce any psychoactive effects until it’s been decarboxylated. Strains that are high in THCa are popular among pediatric and epileptic patients.

THCa helps prevent the growth of cancer cells and is also an anti-spasmodic cannabinoid.

 

CBD FACTS

 

CBD

Cannabidiol (CBD) may be the most promising cannabinoid for people suffering from serious and life-threatening conditions. CBD is a non-psychoactive cannabinoid which can actually reduce or negate the high produced by THC. Consuming strains with a high CBD content will make you less prone to anxiety. For the past 30 years, cannabis has been bred to maximize the THC levels so most strains today contain less than 1% CBD. Because the medicinal benefits of CBD are now more well-known, strains high in CBD are making a comeback. Some of the popular high CBD strains include Cannatonic, Harlequin, and Sour Tsunami.

CBD is useful in slowing down cancer cell growth, inflammation, boosting appetite, arthritis, autoimmune disease, bowel disorders, nausea, diabetes, and many more.

 

CBDa

Cannabidiolic Acid (CBDa) is similar to THCa; it’s the cannabinoid that contains elevated CBD levels. Both THCa and CBDa contain most of the anti-inflammatory properties of cannabis. Heating CBDa turns it into CBD.

CBDa slows down the growth of bacteria and cancer cells, reduces inflammation, and treats nausea and vomiting.

 

CBN

Cannabinol (CBN) is obtained from the degradation of THC. CBN can give a mild high, although most fresh cannabis plants contain very little CBN. It potentiates the THC, can cause drowsiness, and can also contribute to a “couch-lock”. The most pronounced effect of CBN is its sedative effect. It’s rare for dried flowers to contain more than 1% CBN.

CBN aids in pain relief, insomnia, kills bacteria, anti-inflammation, anticonvulsive, stimulates appetite, and promotes the growth of bone cells.

 

CBG

Cannabigerol (CBG) is a non-pscychoactive cannabinoid. CBG is produced with CBGa is heated. Most cannabis strains contain less than 10% CBG although industrial hemp strains contain much higher levels of CBG. Some varieties of industrial hemp have as much as 94% CBG and 0.001% THC. CBG is an antagonist of the CB1 and it’s though that CBG is effective in counteracting a paranoid heady hit caused by strains that are high in THC. Researchers still aren’t sure if CBG plays a role in the CB2 receptor. CBG also inhibits the uptake of GABA in the brain, which results in decreased anxiety.

CBG has anti-inflammatory properties and can benefit patients who suffer from inflammatory bowel disease. CBG is also useful in the treatment of glaucoma and can inhibit tumor growth.


CBC 

Cannabichromene (CBC) may be the least popular of the cannabinoids, but it has promising medicinal properties. CBC can prevent the growth of cancerous tumors, aids in pain and inflammation, and may also help with brain development. CBC works with other cannabinoids to provide a synergistic effect in what we know of as the “entourage effect”.


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